NEW IMPROVEMENTS: Control of the correct coating of the virus particles.
One improvement that it was fundamental to introduce into the formulation of the immune-complex vaccines was the control of the correct coating of the virus particles.
Two new controls have been recently developed in a newly formulated immune-complex vaccine (GUMBOHATCH®, an innovative IBD immune-complex vaccine against Gumboro disease) to achieve this:
• Control of free IgY: this control determines that there are still free Ig Y in the final vaccine suspension, which means that all vaccine particles are necessarily completely coated.
• Neutralization control: this control means the inoculation of the immune-complex to embryonated eggs to prove that all vaccine particles have been “neutralized” through the complete coating with antibodies.
However, other new tests and improvements in the formula have been introduced in order to achieve a better and more consistent production process of the immune-complex vaccines: