Safety and efficacy of an inactivated vaccine against Lactococcus garvieae in rainbow trout (Oncorhynchus mykiss)

Startseite Know-how Safety and efficacy of an inactivated vaccine against Lactococcus garvieae in rainbow trout (Oncorhynchus mykiss)

Safety and efficacy of an inactivated vaccine against Lactococcus garvieae in rainbow trout (Oncorhynchus mykiss)

We studied the safety and efficacy of an inactivated vaccine (Ichtiovac-Lg) against Lactococcus garvieae in rainbow trout (Oncorhynchus mykiss). In an initial dose-response experiment to test safety, we injected 50 rainbow trout weighing 30–40 g with a double dose of vaccine (0.2 ml) intraperitoneally. We observed these fish three times a day until day 50 post-vaccination when they were killed to evaluate visceral reactions, adhesions and intraperitoneal absorption. Survival was 100% in both the treatment and control groups and no significant differences were found in percentage of severe adhesions and pigmentation of peritonea and viscera. In a second trial, we injected 50 rainbow trout weighing 30–40 g with 0.1

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Verfasser

Vendrell, D.; Balcázar, J. L.; Ruiz-Zarzuela, I.; de Blas, I.; Gironés, O.; Múzquiz, J. L.

Zusammenfassung

Our results clearly demonstrate that under our experimental conditions the intraperitoneal vaccination using oil adjuvants in rainbow trout showed some moderate intra-abdominal lesions while major lesions showed lower prevalence, which are considered acceptable by European Pharmacopoeia. Intraperitoneal vaccination 1 month before intraperitoneal experimental challenge with L. garvieae was quite successful: the RPS was 94% (94% survival of the 50 vaccinated trout versus only 4% survival of the controls).

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