5. Why development of cell-mediated immunity against PRRS virus is slow and weak?

Home Knowledge 5. Why development of cell-mediated immunity against PRRS virus is slow and weak?

5. Why development of cell-mediated immunity against PRRS virus is slow and weak?

Hypotheses that could explain this phenomenon:
 

  1. Impairment or enhancement of some cytokines. Impairment of some cytokines such as IFN-α or TNF-α can affect the development of an effective Th1 immune response. Also, the induction of IL-10 by PRRS virus may negatively regulate the cell responses.
     
  2. Interference with correct antigen presentation and activation of T lymphocytes. The PRRS virus down-regulation of given cytokines or of immunologically relevant cell-surface molecules during antigen presentation can affect the development of effective cell responses.
     
  3. Presence of T regulatory (Treg) cells. As seen before, the major function of Treg cells is to down-regulate immune responses. In PRRS virus-infected pigs, a positive correlation has been demonstrated between viraemia and induced Treg cells. These cells have been consistently observed in lymphoid tissues after infection and have been related to TGF-β production. Differences with regards to the ability to generate Tregs could exist among PRRS virus isolates.

 

© Laboratorios Hipra, S.A. All Rights Reserved.
No part of this website or any of its contents may be reproduced, copied, modified or adapted, without the prior written consent of HIPRA.

The contents of this page are country specific and aimed specifically at prescribing veterinarians.

This product is not available in {{ preferredCountry.title }}.

You will be redirected to our global site. Click on continue to visit our global site (available in English).

Confirm that you are a veterinary professional:

This product is not available in {{ countrySelect.title }}.

You will be redirected to our global site. Click on continue to visit our global site (available in English).

  • I am a veterinarian (otherwise please contact a veterinary professional)

Select your country:

Country {{countrySelect.title}}
  • Global (available in English)
  • {{country.title}}