Heterologous cell-mediated immune responses against PRRS virus in gilts vaccinated with UNISTRAIN® PRRS

Inicio Conocimiento Heterologous cell-mediated immune responses against PRRS virus in gilts vaccinated with UNISTRAIN® PRRS

Heterologous cell-mediated immune responses against PRRS virus in gilts vaccinated with UNISTRAIN® PRRS

Vaccination is one of the main tools to minimize porcine reproductive and respiratory syndrome (PRRS) impact in endemic areas. Current knowledge of PRRS virus (PRRSV) immunology is still limited but it seems clear that modified live vaccines (MLV) are a reasonable choice for the immunization of pigs.

Sobre este artículo

Apareció en

International PRRS Congress, 2015

Autores

Miranda,J.; Rodriguez-Ballarà, I.; Fenech, M.; Perozo, E.; Llopart, D.; Torrents, D.; Mateu, E.; Díaz, I.

Resumen

Genetic/antigenic diversity and variability in the immunobiological properties of the PRRSV (3,4) may compromise the heterologous protection generated by vaccination in PRRS control strategies. Although PRRS immunity is not yet fully understood, the significance not only of the NA but the cell-mediated immunity is important for a better understanding of vaccine performance (3). The present study showed that primo-immunization of naïve gilts with UNISTRAIN® PRRS induced a significant specific cell-mediated immunity against 5 heterologous PRRSV strains. The mean IFN-γ-SC response was significantly higher than non-vaccinated group regardless the virus strain origin, year of isolation and genetic homology. Briefly, the results demonstrate that a single immunization with UNISTRAIN® PRRS of replacement gilts can generate an optimal cell-mediated response against pathogenic field PRRSV.

Productos relacionados

Compartir en